5-HT3 antagonist 5

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5-HT3 antagonist 5 是一种喹喔啉 -2- 甲酰胺化合物，是 5-HT3 受体拮抗剂。5-HT3 antagonist 5 对 5-HT3 激动剂和 2- 甲基 -5-HT 也具有拮抗作用，并在小鼠中表现出抗抑郁效果。

5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.

5-HT3 antagonist 5 (compound 4c) exhibits 5-HT3 receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methyl-5-HT, with pA2 value of 5.

5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice.Animal Model:Swiss albino mice (23 ± 2 g) Dosage:1 mg/kg Administration: Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration Result:Reduced the duration of immobility as compared to the vehicle-treated (control) group.Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity.

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Others

Other Targets

Others

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901599-43-7

279.29

C16H13N3O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 20.83 mg/mL (74.58 mM; 超声助溶 (<60°C)

COc1ccc(NC(=O)c2cnc3ccccc3n2)cc1

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(-20℃)

With Ice Pack

≥ 2 years